SEDATIVE AND HYPNOTICS
Pentobarbitone sleeping time
Vomtrol, standard, test
Mice
Writhing time
Sleeping time
On 7th day_ 25 to 30mg per kg
After dose… latency to sleep…
10min… Duration of sleep- calculation of the sleep hours from start to wake up.
Drug- sedative in comparison should be increased
Control comparison
List of the sleeping hours
EXPERIMENTAL MODEL FOR ANTI_ PARKISONISM
Animal model we cannot get direction anto,, measure the symptoms >>> oxytrimor model is used to assess
Model test for muscle- muscle tone- rota rod
Riserpine induced catatonia model
Oxytoxin 80mg/kg
– salivation, lacrimation, tremor, ataxia moment, jerk moment of present
– Assessment – 10min, 20min, 60min,120min after giving th medicine
– 0- no, 1- mild, 2- moderate, 3- rigid
– Assessment for tremor, .. all of them
Reserpine induced catatonia
100mg/kg
Assessment
– Catatonia- iif placed one leg upside,,, muscle rigidiy occur and remiam for same position
– Ptosis
– Sedative
– Hypothermia
Grading- 1,2,3
0,1,2,3,4,5,6 hour assessment
Rota rod apparatus
For assessing muscle rogidity
Antipsychotic model
Instrument
– radial maize apparatus
– Tunnel apparatus
– Exploratory behavior whole body
– Cooks pool climbing apparatus
Assessment present of CAR- conditions awareness response
– bell or shock
– Response- climbing
Alarm.
No alarm
– two cases
Shock without alarm- jump (car)
Before alarm- cam present
And after- cam absent
If cam present – antipsychotic present
antiparkinoism
– grip stain meatsr
– Hold the mess
– Pull the tail
– Gnawing started
– Holding strength if the rat will be assessed
Exploitative behavior